Mechanisms and principles of N- linked protein glycosylation. N- linked glycosylation, a protein modification system present in all domains of life, is characterized by a high structural diversity of N- linked glycans found among different species and by a large number of proteins that are glycosylated. Based on structural, functional, and phylogenetic approaches, this review discusses the highly conserved processes that are at the basis of this unique general protein modification system. Protein glycosylation has multiple functions in the cell. In the ER, glycosylation is used to monitor the status of protein folding, acting as a quality.Protein glycosylation: nature, distribution. It is the aim of this review to describe the glycopeptide linkages that have been.
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January 2017
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